Laboratories

Laboratory of Structural Biology of Macro-Molecular Complexes Recruiting students for the academic year 2018

Associate Professor Shuya FUKAI
+81-3-5841-7807
E-mail: fukai{at}iam.u-tokyo.ac.jp
Lab HP

Introduction

【Key Words】protein, structural analysis, ubiquitin, neuroscience, signal transduction

 Biological macromolecules are folded to exert their specific functions. Therefore, three-dimensional structure determination is necessary to elucidate how the biological macromolecules work. X-ray crystallography is a powerful structure determination method in terms of resolution and applicable molecular weight. The mission of our laboratory is elucidation of regulatory mechanisms for molecular signaling and reactions inside or outside cells at atomic resolution by X-ray crystallography of biological macromolecular complexes. We further perform functional analyses using site-directed mutants in vitro and/or in vivo to support the principle of the complex formation and the functional mechanism which are revealed by the threedimensional structure of the macromolecular complex.

Laboratories

The University of Tokyo
Graduate School of Frontier Sciences, The University of Tokyo

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