Laboratories

Laboratory of cellular and Molecular Biology Recruiting students for the academic year 2018

Professor Jun-ichiro INOUE
+81-3-5449-5275
E-mail: jun-i{at}ims.u-tokyo.ac.jp
Lab HP

Associate Professor Taishin AKIYAMA
+81-3-5449-5276
E-mail: taishin{at}ims.u-tokyo.ac.jp

Introduction

【Key Words】signal transduction, cancer, bone metabolism, immunity

 The themes pursued in our laboratory are related to “cancer”, immunity”, and “bones”, since signal transducer TRAF6 and transcription factor NF-κB,which we are interested in, are profoundly involved in tumorigenesis, immune regulation, and bone metabolism. Upon cytokine stimulation, TRAF6 acts as an E3 ubiquitin ligase to generate Lys-63-linked polyubiquitin chains, which do not induce proteasomal degradation, but rather act as platforms for formation of active signal complexes leading to the activation of NF-κB. A number of serious human diseases are caused by various kinds of bone metabolism abnormalities and immunodeficiencies. We were able to reproduce diseases similar to these human diseases in TRAF6- or NF-κB-deficient mice, indicating that TRAF6/NF-κB signals are essential for normal bone formation and the establishment of immunity. Abnormal activation of NF-κB also plays a critical role in the onset and progression of various leukaemias and many other cancers. We are trying to elucidate how dysregulation of TRAF6/NF-κB signaling leads to malignant transformation, immunoregulation, and bone metabolism at the molecular level and we are conducting numerous experiments on gene transfer into cultured cells and analyses of various knockout mice, aiming to put the results to use in drug discovery and the diagnosis and treatment of diseases. Details are shown in the Lab web site (URL:http://www.traf6.com) .

Laboratories

The University of Tokyo
Graduate School of Frontier Sciences, The University of Tokyo

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