Laboratories

Laboratory of Bioinformatics and Systems Biology (Department of Biological Sciences, Graduate School of Science) Recruiting students for the academic year 2018

Associate Professor Wataru IWASAKI
Department of Biological Sciences, Graduate School of Science
E-mail: iwasaki{at}bs.s.u-tokyo.ac.jp
Lab HP

Intoduction

【Key Words】bioinformatics, genome, metagenomic, evolution, animal behavior

Providing new insights into life

 Our laboratory aims at providing new insights into life through bioinformatic approaches.

 Technological innovations in the life science domain have enabled us to obtain and analyze massive amount of data that can unveil the underlying principles of Life and its evolutionary history. While genomic data provide an overview of the history of life over hundreds of millions of years, other omic data illustrate how genomic sequences perform their functions about, for example, gene expression, regulation, and interactions. Pathway and network data represent diverse biological knowledge in a machine-understandable manner that permits large-scale computational analyses. Bioimaging and biologging data provide ways to quantitatively characterize phenotypes and behavior of organisms. Last but not least, metagenomic, ecogenomic, and environmental DNA data illustrate complex interactions between Life and environments.

 To understand life, it is fundamentally important to integrate and analyze these data comprehensively, not partially. In this context, utilizing deep understanding of both biology and informatics, we aim to uncover new concepts, insights, and laws behind life systems.



Fig . Providing new insights into the life through bioinformatic approaches

Evolution of genomes and their functions

 Genomic information reflects the long history from our ancient ancestors to the current day while also serving as the foundation of all biological activities. The analysis of genomic evolution is a scientific endeavor that aims at answering questions such as how Life has evolved from the common ancestor, and how the genomes and the biological systems they encode have been developed.

 Transcriptomic data tell us about the identity and expression level of genes that exist within genomes, and metagenomic data provide a compositional view of complex microbial ecosystems. Both are treasure troves of information. By analyzing the dynamics between these omic datasets over various environmental conditions, we aim to understand how Life responds to environmental changes and what kind of interactions and inter-relationships exist between them.

Other frontiers of bioinformatics

 Bioimaging and biologging data are important resources for quantitatively analyzing phenotypes and behavior of organisms. In out laboratory, new information technologies for analyzing those types of data are being developed. Other related research topics involve data visualization, text mining, and bibliographic analysis.

Joining our laboratory as a graduate student

 We welcome students who are eager to learn and understand both biology and informatics and to conduct interdisciplinary researches. In particular, those who majored bioinformatics and/or were involved in research projects related to bioinformatics during their undergraduate or master courses, and aim at earning a Ph.D will be welcome. If you are interested in joining our laboratory, please send an email to PI first.

 Notes: We have experience in accepting students from outside of Japan. Japanese language is not mandatory if you have enough English skills; however, a will to learn Japanese would be necessary because it makes you enjoy Japan more and many optional classes are held in Japanese. As the University of Tokyo provides Japanese language classes, we usually encourage colleagues from abroad to take them. You may obtain further information on our laboratory website.

Laboratories

The University of Tokyo
Graduate School of Frontier Sciences, The University of Tokyo

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