Laboratories

Laboratory of Systems Biology does not recruit students for the academic year 2018

Associate Professor Susumu NAKAE
+81-3-6409-2111
E-mail: snakae{at}ims.u-tokyo.ac.jp
Lab HP

Introduction

【Key Words】animal model of diseases, allergy, autoimmunity, cytokine

 Our lab uses techniques such as omics analysis to search for genes thought to contribute to the pathology and pathogenesis of refractory chronic inflammatory diseases such as allergy and autoimmunity. We produce and study candidate gene-modified mice for functional analysis of disease development.
 ・Searching for genes related to allergies
 ・Generation of mice with modified candidate genes
 ・Analysis of allergy models using these mice. Models include asthma, dermatitis, rhinitis, and food allergies.
 Our lab studies the pathogenesis of allergic diseases,focusing on IL-17 produced by Th17 cells and IL-33, which activates mast cells. We have also applied omics analysis to identifying genes responsible for allergy onset. We hope that our findings will provide the foundation for preventing and treating these diseases.  Website:
http://www.ims.u-tokyo.ac.jp/imsut/en/lab/experimentalmedicine/


 Mouse model of skin inflammation
 Knocking out a specific gene causes these mice (A-C )to develop skin inflammation immediately after birth.
 Control mice (D-F) are normal littermates.


IL-33による喘息誘導機構

Laboratories

The University of Tokyo
Graduate School of Frontier Sciences, The University of Tokyo

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