Division of RNA and Gene Regulation

Professor Toshifumi Inada
E-mail: toshiinada[at]
Lab HP


【Key Words】Translation quality control, RNA regulation, Ribosome, Ubiquitination, Proteostasis, Proteasome, Ribosomopathys

To decipher the mechanism to ensure the fidelity of protein synthesis

 The field of biology has expanded from the traditional approaches of focusing on specific organisms and phenomena to utilizing data science approaches in the pursuit of obtaining a comprehensive understanding of life. Under this context, our laboratory employs interdisciplinary approaches, including but not limited to: bioinformatics, laboratory experiments, mathematics, and field samplings to study evolution and ecology of diverse life forms, and to develop novel biotechnological methods.

Topics and Questions

(1) Molecular mechanism of quality control RQC that guarantees translation accuracy:How are translation anomalies perceived, and how are anomalous proteins decomposed and eliminated? (2) Physiological significance of translation quality control in nerve cells: What kind of abnormal translation occurs in nerve cells and is recognized and eliminated by quality control? (3) Ribosome abnormalities and diseases: How are abnormal ribosomes recognized and eliminated?How do diseases caused by ribosome abnormalities develop? (4) Aging and translation accuracy: What is the substance of protein homeostasis due to aging?

The related research fields and research areas are as follows.
[Genetics / Biochemistry] Translation quality control / RNA expression control
[Cell biology/neuroscience] Neuronal cell death and disease onset mechanism due to disruption of protein homeostasis
[Structural biology] Single particle analysis of ribosomes and quality control factors using cryo-electron microscopy

Joining our laboratory as a graduate student

We welcome those who aspire to develop new research fields by acquiring a wide range of different research methods from genetics, biochemistry, and cell biology to structural biology and neuroscience.

We are currently accepting graduate students only from Department of Integrated Biosciences (Graduate School of Frontier Sciences, UTokyo) and Department of Biological Sciences (Graduate School of Science, UTokyo). Please visit websites of those departments for details.

Publications in the last several years contributed by graduate students

Udagawa, Seki, Okuyama et al., Cell Rep. 2021; Mizuno et al., NAR 2021; Buschauer, Matsuo et al., Science 2020; Matsuki and Matsuo et al., Sci Rep 2020; Matsuki and Matsuo et al., BBRC 2020; Matsuo et al., NSMB 2020; Hashimoto et al., Sci. Rep. 2020; Hashimoto et al., FEBS Letters 2019; Sugiyama, Li, Kato et al., Cell Rep. 2019; Ikeuchi et al., EMBO J. 2019


The University of Tokyo
Graduate School of Frontier Sciences, The University of Tokyo

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