Professor: Tomoji MASHIMO Prof. Mashimo came to the University of Tokyo and set up this new laboratory in June, 2019. The genome editing technology (ZFN, TALEN, CRISPR/Cas, etc.) brought a revolution in the development of medical science and life science. By using this technology, we can easily operate genomes in different human cell lines or laboratory animals, which is widely applied in investigation of genes’ function, generating animal models for human diseases, gene therapy and so on. The main subjects in our laboratory including: (1) development of novel genome editing system, CRISPR/Cas3, and related application in the cell therapy and gene therapy for human diseases; (2) generation if new animal models by conducting genome editing in animal zygotes, especially the humanized animals which are modified by human genome. Furthermore, we are also working on developing humanized animals with human organs by transplanting human somatic cells or iPS cells into immunodeficient animals. Following is the detail research interests in our laboratory:
