Medical Sciences Group/Intra-University Cooperative LaboratoriesYamazaki Laboratory
(Division of Cell Regulation, IMS)
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Professor YAMAZAKI Satoshi
Our studies focus mainly on investigation of stem cell biology using the hematopoietic stem cell (HSC) as a research model. Recent identification of a variety of stem cell sources including embryonic and somatic (tissue-specific) stem cells has brought about substantial progress in the field of stem cell research. The HSC represents the first stem cell for which identity and existence were determined. Studies on HSCs have provided us with some basic concepts applying to different types of stem cells, yet many of these concepts remain unverified. It therefore is very important to continue basic studies to answer many questions left unsolved and thus to permit contributions to the field of biological research and clinical medicine. HSCs are capable of continuous supply of all lineages of blood cells to each individual for his or her entire life. Both self-renewal and multilineage differentiation potentials enable this task. One major advantage in HSC research lies in that established assay systems allow clonal analysis of each individual stem cell. Using a defined assay system, we can test capabilities of self-renewal and multilineage differentiation at single cell levels using either in vitro or in vivo assays. We believe that HSC research will eventually make great contributions to the development of safe and efficacious regenerative medicine and gene therapy.
- Research
keywords - Stem Cell Biology, Gene and Cell Therapy
Stem cell biology focused on hematopoietic stem cell research
Our aim is to understand and control the undifferentiated nature and pluripotency of stem cells, with a focus on hematopoietic stem cells.
We also aim to construct a new cell therapy system using our established cell control technology.