Medical Sciences Group/Intra-University Cooperative LaboratoriesYamanashi Laboratory
(Division of Genetics, IMS)

The major interest of this laboratory is in molecular signals that regulate a variety of cellular activities. Our aim is to address how dysregulated cellular signals give rise to neoplastic, immune, neural, metabolic, developmental and/or age-related disorders. Our goal is to understand the molecular bases of tumorigenesis and the development of other intractable diseases as a path toward uncovering therapeutic targets. For example, we identified Dok-7 as an essential protein for neuromuscular synaptogenesis and found DOK7 myasthenia, a recessive hereditary neuromuscular synaptopathy. We further demonstrated that elevated Dok-7 expression, or any equivalent method that safely enlarges neuromuscular synapses, has potential as a therapy for a range of neuromuscular disorders with structural defects in neuromuscular synapses.  Currently, we are investigating regulatory mechanisms in protein-tyrosine kinase-mediated signaling pathways, their pathophysiological roles and the potential for therapeutic intervention.  Our website: Laboratories Group of Medical Sciences Group of Computational Biology Group of Innovation Policy Studies Campus The University of Tokyo Graduate School of Frontier Sciences, The University of Tokyo

signal transduction, mouse model, gene/molecular targeted therapy, neoplasia/immunity, ageing/neuromuscular disorder
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